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Spravato

What is Spravato (Esketamine)?

Spravato is an FDA-approved prescription nasal spray administered under clinical supervision. It is specifically designed for adults who have:

  • ​Treatment-Resistant Depression (TRD): Persistent symptoms after trying at least two different oral antidepressants.​

  • Major Depressive Disorder (MDD) with Suicidal Ideation: Depressive symptoms accompanied by active suicidal thoughts or actions.

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The Treatment Experience

Spravato is used alongside an oral antidepressant in three distinct phases:

  • Induction (Weeks 1–4): Two treatments per week.

  • Transition (Weeks 5–8): One treatment per week.

  • Maintenance (Weeks 9+): One treatment every 1 to 2 weeks, depending on your individual progress and symptom remission.

Important: Because Spravato can cause sedation or dissociation, you must remain at the clinic for at least two hours of observation after each dose. You will also need to arrange a ride home, as you cannot drive until the following day after a restful sleep.

FDA Regulation:

Unlike IV ketamine, Spravato is specifically FDA-approved for depression and is covered by most major insurance plans.​

Insurance & Support

Spravato is widely covered by insurance providers. Most clinics have dedicated specialists to manage the REMS (Risk Evaluation and Mitigation Strategy) enrollment and paperwork required to ensure your treatment is authorized and covered.

Medical Cannabis Certification

Compassionate care meets clinical expertise. We specialize in medical cannabis evaluations, helping patients understand the therapeutic benefits of cannabis for their specific conditions. Our provider offers the bona fide patient-practitioner relationship required by law to help you legally and safely obtain your medical card.

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How it Differs from Ketamine

While Spravato is derived from ketamine, it is not the same thing:

  • Targeted Molecule: Spravato contains esketamine, a specific molecule found within ketamine that is more potent at certain brain receptors.

  • Lower Dosing: Its higher potency allows for lower clinical doses, which may reduce potential side effects compared to standard ketamine infusions.

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